The Prevalence Of Autonomic Dysfunction And Fac Tors...

DISCUSSION This study was performed to assess the prevalence of autonomic dysfunction, and fac-tors affecting CAN. The study included 56 eligible participants with T2DM. Our study reveals that a significant proportion of patients with T2DM have CAN. Study found that overall 85% of persons with T2DM have CAN (combined early and definite CAN). Mean fasting blood glucose and BMI were significantly associated with CAN in type 2 DM. Parasympathetic involvement was more than sympathetic involvement. Out of all tests performed, heart rate response to standing (EI ratio) and deep breathing (30:15 ratio) were the most common test affected in our study population. S. Aggarwal et al [41] in their study on 50 patients with non cardiac Diabetes Mellitus had demonstrated 70% of patients were tested positive for autonomic dysfunction, however our study reports 85% patient to have autonomic dysfunction.In our study , 8(14%)had no CAN, 24 (42%) had early CAN, and 24 (42%) had definite CAN. A study by Angadi sumaswi et al [42], 32% (16) patients had no CAN. Early CAN was seen in 14% (7), severe CAN in 14% (7), definite CAN in 8% (4) patients. Atypical CAN with other combination of abnormalities was seen in 32% (16) patients. Various studies shows different prevalence of CAN ranging from 58% to 70 % [43-45]. The most common abnormality observed was heart rate response to standing(68%), followed by deep breathing( 64%). Heart rate response to valsalva was the least affected (30%)